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Abstract #3468

Functional Diffusion Tensor Imaging in the Evaluation of Early Response After Radiosurgery in Patients with Acoustic Neuroma

Yu-Chun Lin1, Yau-Yau Wai1, Chun-Chieh Wang2, Jiun-Jie Wang3

1Department of Diagnostic Radiology, ChangGung Memorial Hospital, KweiShan, Taoyuan, Taiwan; 2Department of Radiation Oncology, ChangGung Memorial Hospital; 3Department of Medical Imaging and Radiological Science, ChangGung University, Taoyuan, Taiwan

This study prospectively investigated the early response after radiosurgery in patients with acoustic neuroma using functional diffusion tensor imaging (DTI). Five patients underwent longitudinal DTI studies on a 3T MR scanner up to 6 months. Posttreatment DTI data were spatially coregistered with pretreatment scans. The mean diffusivity, fractional anisotropy, and intervoxel diffusion coherence were calculated using simple average methods and functional diffusion maps. The Results showed tumors did not change in size after treatment while diffusion indices changed significantly during the study period. Functional diffusion tensor imaging provides the possibility of assessing the acute response in this patient group.