Meeting Banner
Abstract #3542

Diffusion Sensitization Direction Dependence of Biexponential Diffusion Decay Parameters in the Splenium

Robert Vincent Mulkern1, Richard Lee Robertson1, Stephen John Haker2, Dimitrios Mitsouras2, Stephan E. Maier2

1Radiology, Children's Hospital, Boston, MA, USA; 2Radiology, Brigham and Women's Hospital, Boston, MA, USA

The dependence of biexponential parameters characterizing diffusion decay curves from the splenium on the angle between fiber direction and diffusion sensitization direction was examined. An angular dependence of the slow diffusion coefficient consistent with current models was obtained. A similar angular dependence for the fast fraction amplitude and the fast diffusion coefficient was also found, features which are not explained by current models.