Diffusion Sensitization Direction Dependence of Biexponential Diffusion Decay Parameters in the Splenium

Robert Vincent Mulkern¹, Richard Lee Robertson¹, Stephen John Haker², Dimitrios Mitsouras², Stephan E. Maier²

The dependence of biexponential parameters characterizing diffusion decay curves from the splenium on the angle between fiber direction and diffusion sensitization direction was examined. An angular dependence of the slow diffusion coefficient consistent with current models was obtained. A similar angular dependence for the fast fraction amplitude and the fast diffusion coefficient was also found, features which are not explained by current models.