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Abstract #3553

Probabilistic Tractography Driven White Matter Width Measurement

Hojjatollah Azadbakht1, David Mark Morris1, Hamied Ahmed Haroon1, Karl V. Embleton1,2, Brandon J. Whitcher3, Julie Snowden4, Geoff J. Parker1

1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK; 2School of Psychological Science, University of Manchester, Manchester, UK; 3Clinical Imaging Centre, GlaxoSmithKline, London, UK; 4Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK

This work introduces a novel approach to quantify the width of the White Matter (WM) structures in the brain. The PICo tractography method was used to extract the Uncinate Fasciculus (UF) from both hemispheres of 10 normal datasets. An electric field model was used to generate the curve-skeletons of the extracted tracts. Subsequently, using the generated electro-static vector fields, for each point along the curve-skeletons, the mean geodesic distance from the surface to the skeleton was computed. Seven of the subjects demonstrated right hemisphere lateralization, where the right UF had a higher mean width score than the left.