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Abstract #3561

Sex Differences in the Human Corpus Callosum Microstructure: T2 Myelin-Water Imaging Versus Diffusion Tensor Imaging

Logi Vidarsson1, Fang Liu2, Andrea Kassner2,3

1Diagnostic Imaging, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada; 2Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, ON, Canada; 3 Medical Imaging, The University of Toronto, Toronto, ON, Canada

The corpus callosum plays an important role in relaying sensory, motor and cognitive function between cerebral hemispheres. Females seem to employ a greater degree of bilateral hemispheric activity than males and also have a larger callosal area in proportion to brain volume, which suggests that a larger number of fibres are passing through. In this study we have compared short T2 myelin-water imaging to DTI in the corpus callosum of healthy volunteers. Our findings suggest that male fibers are less densely packed compared to female fibres but contain more myelin as reflected by the difference in myelin-water values.