Abstract #3565

Effect of Reference Template Selection in Diffusion Tensor Based Voxel-Wise Analysis

Hsuan-Hui Wang¹, Kun-Hsien Chou², Pei-Chin Chen¹, I-Yun Chen³, Ching-Po Lin^1,3

¹Institute of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; ²Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; ³Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

Diffusion tensor based voxel-wise analysis (DT-VBA) has been increasingly used to investigate subtle inter-group differences in brain white matter integrity on a voxel-wise basis in a standardized space. However, varieties of reference template and procedures of processing exist in the implementation of DT-VBA. In order to realize the effect of different DT-VBA procedures, the purpose of this study is to systematically evaluate the effects and accuracy of varying reference template and image preprocessing procedure of the DT-VBA. The results indicate that using the modality-matched template for normalization could diminish the distortion and improve the accuracy for spatial normalization in DT-VBA.