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Abstract #3616

Quantitative Mapping of Cerebral Blood Flow Change Using Phase Information of SWI

Yuri Zaitsu1, Kohsuke Kudo2, Rie Yazu1, Kinya Ishizaka3, Noriyuki Fujima1, Khin Khin Tha1, Satoshi Terae1, Makoto Sasaki2, Hiroki Shirato1

1Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan; 2Advanced Medical Research Center, Iwate Medical University, Japan; 3Radiology, Hokkaido University Hospital, Japan

Phase image of susceptibility weighted imaging (SWI) offers information of oxygen saturation by using the phase shift of the spin derived from the paramagnetic substances. It is possible to achieve automated calculation to make a whole brain mapping of cerebral blood flow (CBF) changes. Our automated method to calculate blood flow changes (∆) yields stable and reliable ∆ value, compared to the manual measurements. Moreover, the good agreement between ∆ of SWI and ∆CBF of arterial spin labeling data with respiratory challenge suggests that our automated map could be an alternative and non-invasive tool for CBF measurement.