Lesley M. Foley1, Mioara D. Manole2, T Kevin Hitchens1,3, Patrick M. Kochanek4,5, Robert W. Hickey2, Henry L. Alexander4, Hulya Bayir2,6, Chien Ho1,3, Robert S. Clark2,7
1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, USA; 2Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; 3Department of Biological Science, Carnegie Mellon University, Pittsburgh , PA, USA; 4Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA; 5Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh , PA, USA; 6Department of Critical Care Medicine, University of Pittsburgh , Pittsburgh , PA, USA; 7Department of Critical Care Medicine, University of Pittsburgh , Pittsburgh, PA, USA
Colloids such as albumin and polynitroxyl albumin (PNA), a highly nitroxylated antioxidant form of albumin, resulted in improved CBF in models of focal ischemia. The effect of resuscitation with colloid on CBF after CA remains to be defined. PNA given at resuscitation from CA decreased the initial hyperemia, while albumin produced a more prolonged and intense hyperemic response in all brain regions. The mechanisms responsible for these CBF changes and the effects of albumin and PNA given at resuscitation on neurological outcome remain to be determined.
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