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Abstract #3647

Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D Spiral SE Arterial Spin Labeling on 3T-MR: Correlative Study with O15 Labeled H2O PET Examination.

Hirohiko Kimura1, Hidehiko Okazawa2, Tsuyoshi Matsuda3, Yoshikazu Arai4, Asit Shankaranarayanan5, David Alsop6

1Radiology, University of Fukui, Eiheiji, Fukui, Japan; 2Biomedical Imaging Center, University of Fukui, Eiheiji, Fukui, Japan; 3GE-YMS, Hino, Tokyo, Japan; 4Neurosurgery, University of Fukui, Eiheiji, Japan; 5GE Helthcare, USA; 6Radiology, Beth Israel Deacones Medical center, Boston, MA, USA

Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral blood flow. However, it has not been investigated whether the hemodynamic changes in patients with occlusive cerebrovascular disease which affect the utility of ASL. The goal of the current study is to demonstrate arterial transit map calculation as well as CBF based on a two-compartment model using a 3D spiral SE sequence. The comparison of CASL-CBF and O15 labeled H2O PET-CBF was also performed for the validation of delay compensated CBF values in patients with chronic occlusive cerebrovascular disease.