Abstract #3647

Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D Spiral SE Arterial Spin Labeling on 3T-MR: Correlative Study with O15 Labeled H2O PET Examination.

Hirohiko Kimura¹, Hidehiko Okazawa², Tsuyoshi Matsuda³, Yoshikazu Arai⁴, Asit Shankaranarayanan⁵, David Alsop⁶

¹Radiology, University of Fukui, Eiheiji, Fukui, Japan; ²Biomedical Imaging Center, University of Fukui, Eiheiji, Fukui, Japan; ³GE-YMS, Hino, Tokyo, Japan; ⁴Neurosurgery, University of Fukui, Eiheiji, Japan; ⁵GE Helthcare, USA; ⁶Radiology, Beth Israel Deacones Medical center, Boston, MA, USA

Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral blood flow. However, it has not been investigated whether the hemodynamic changes in patients with occlusive cerebrovascular disease which affect the utility of ASL. The goal of the current study is to demonstrate arterial transit map calculation as well as CBF based on a two-compartment model using a 3D spiral SE sequence. The comparison of CASL-CBF and O¹⁵ labeled H₂O PET-CBF was also performed for the validation of delay compensated CBF values in patients with chronic occlusive cerebrovascular disease.