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Abstract #3669

First Demonstration of SS-PARSE in Detecting the BOLD Effect in Humans

Edward Walsh1,2, Donald Twieg3, Michael Worden1,2, Stanley Reeves4, Jerome Sanes1,2

1Department of Neuroscience, Brown University, Providence, RI, USA; 2Institute for Brain Science, Brown University, Providence, RI, USA; 3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA; 4Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA

The SS-PARSE (Single-Shot Parameter Assessment by Retrieval from Signal Encoding) technique addresses difficulties relating to conventional MR reconstruction methodology by modeling raw data as evolving in time (k,t-space). Using a nonlinear optimization process to provide an inverse solution to the MR signal equation, the SS-PARSE reconstruction produces parametric maps of magnetization, R2*, and frequency from a single-shot signal. In this report, the first demonstration of BOLD activation detection in humans using SS-PARSE is presented.