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Abstract #3673

Activity-Based Seed Regions for Resting-State FMRI Analysis Are Susceptible to Large Vessels

Ali Mohammad Golestani1, Bradley Goodyear2

1Electrical & Computer Engineering, University of Calgary, Calgary, Alberta, Canada; 2Radiology & Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada

Because task-related BOLD fMRI is susceptible to large vessels, the objective of this study was to compare the location of seed regions for resting-state connectivity analysis based on task-related maps to those based on an anatomical approach. Overlap between the two methods was not considerable, suggesting that task-based and anatomical-based seeds do not converge upon the same region. Task-based seeds were located at more superior locations in the brain in proximity to large draining vessels, as compared to anatomy-based seeds. Hence, seed regions based on brain activity in response to tasks may not be optimal for analysis of resting-state networks.