Dynamic Windowing Reveals Task-Modulation of Functional Connectivity in Schizophrenia Patients Vs Healthy Controls

Unal Sakoglu¹, Vince D. Calhoun¹

In this work, a dynamic time-window analysis approach was developed to assess functional network connectivity during change from no-task to task condition and vice versa. The approach was applied to fMRI data from chronic schizophrenia patients and matched healthy controls under an auditory sensory-motor task with block design. It was observed that the connectivity of task-related networks with other networks consistently decreases(increases) in healthy controls when switching to(from) the task condition (in ~8s), a phenomenon which was not as much pronounced in the schizophrenia patients.