Abstract #3679

Slice-Timing Correction Affects Functional MRI Noise, Model Fit, Activation Maps, and Physiologic Noise Correction

Keith Michael Vogt^1,2, James W. Ibinson³, Robert H. Small^1,2, Petra Schmalbrock⁴

¹Anesthesiology, The Ohio State University, Columbus, OH, USA; ²Biomedical Engineering, The Ohio State University, Columbus, OH, USA; ³Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; ⁴Radiology, The Ohio State University, Columbus, OH, USA

Interleaved slice-timing correction (STC) in the analysis of pain functional MRI data was investigated for its effects on timecourse temporal standard deviation, model fit, activation maps, and slice-wise respiratory noise correction. Interaction between slice-timing and respiratory correction was demonstrated for all three FMRI study outcome measures. Both corrections caused decreases in timecourse noise and the model fit improvements from STC were much smaller than from respiratory correction. This indicates that STC affects the impact of respiratory noise correction and also that respiratory correction is more important than STC in the detection of block-design task FMRI activation.