Abstract #3696

Accompanying Event-Related Decrease of Alpha Band EEG and Sustained Negative BOLD Response at Ipsilateral Primary Sensorimotor Area

Han Yuan¹, Rebecca Szarkowski¹, Cristina Rios¹, James Ashe^2,3, Bin He^1,2

¹Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; ²Neuroscience, University of Minnesota, Minneapolis, MN, USA; ³Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN, USA

The aim of the study is to investigate the biophysical relationship between task-induced responses of BOLD-fMRI and electrophysiological signals in alpha-frequency band (8 13 Hz). We combined electroencephalography (EEG) and fMRI to identify the correlates of negative BOLD response in a motor paradigm. Our results showed co-localization of task-related decrease of alpha band EEG and sustained decrease of BOLD signals at the ipsilateral primary sensorimotor area, which indicates a neural correlate of negative BOLD response and suggests that decreased neural activity may cause the desynchronization of alpha rhythm.