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Abstract #3696

Accompanying Event-Related Decrease of Alpha Band EEG and Sustained Negative BOLD Response at Ipsilateral Primary Sensorimotor Area

Han Yuan1, Rebecca Szarkowski1, Cristina Rios1, James Ashe2,3, Bin He1,2

1Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; 2Neuroscience, University of Minnesota, Minneapolis, MN, USA; 3Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN, USA

The aim of the study is to investigate the biophysical relationship between task-induced responses of BOLD-fMRI and electrophysiological signals in alpha-frequency band (8 13 Hz). We combined electroencephalography (EEG) and fMRI to identify the correlates of negative BOLD response in a motor paradigm. Our results showed co-localization of task-related decrease of alpha band EEG and sustained decrease of BOLD signals at the ipsilateral primary sensorimotor area, which indicates a neural correlate of negative BOLD response and suggests that decreased neural activity may cause the desynchronization of alpha rhythm.