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Abstract #3698

Time Invariant BOLD Impulse Response Functions for Brief- And Long-Lasting Stimuli

Peter Herman1,2, Basavaraju G. Sanganahalli1, Hal Blumenfeld3,4, Fahmeed Hyder1,5

1Diagnostic Radiology, Yale University, New Haven, CT, USA; 2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary; 3Neurology, Yale University, New Haven, CT, USA; 4Neurobiology, Yale University, New Haven, CT, USA; 5Biomedical Engineering, Yale University, New Haven, CT, USA

Quantitative mapping of changes in CMRO2 with BOLD calibration has become a popular modality for studying functional brain activity because it is proportional to changes in energy consumption associated with alterations in neuronal activity. The calibrated fMRI is based on steady-state tissue oxygen extraction model, and it is unclear whether calculation of CMRO2 will differ between short and long stimuli. We show that the linear convolution analysis can characterize a single transfer function for short and long stimuli, even with varying stimulation conditions. This experimental approach provides a basis for the use of calibrated fMRI in a dynamic manner.