Calibrating the BOLD Signal Revisited Calculation of Oxygen Metabolism for Gradient- And Spin-Echo Sequence Up to 16.4T

Kamil Uludag¹, Anne-Catherin Zappe¹, Jozien Goense¹, Nikos K. Logothetis¹

A BOLD signal model as a function oxygen extraction fraction and CBV was developed in order to determine change in oxidative metabolism from combined BOLD signal and CBF measurements. The new model is an alternative model to the widely used calibrated BOLD approach initally proposed by Davis and colleagues for GRE at 1.5T. The new model, however, takes also intra-vascular MRI signal into account and is developed for both GRE and SE from 1.5T up to 16.4T. In the current study, at 4.7T and 7T using SE and GRE, oxidative metabolism change during visual stimulation was determined in macaque monkeys.