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Abstract #3732

Reliability of a Breath-Hold Paradigm to Characterise Inter-Subject Differences in Cognition Based Bold Contrast

Marie Tisserand1, Fernando Zelaya2, Owen O'Daly2, Alejandro Caceres2, Laurence Reed3, Mitul Mehta2

1Department of Neuroradiology, Nancy University Hospital, Nancy, France; 2Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK; 3Section of Addiction Sciences, Institute of Psychiatry, London, UK

The utility of breath-hold challenges for the characterisation of the vascular contribution to the BOLD response in different subjects, depends on their ability to elicit reliable and reproducible signals across different sessions. The intra-class correlation coefficient (ICC) has been proposed as a means of obtaining a voxel-wise measure of reliability in scans collected at different time points. We generated group-wide ICC maps from 18 subjects who executed a breath-hold challenge in two separate sessions. Maps show remarkably high reliability in grey matter suggesting that these challenges could be used reliably if collected at different time points