Meeting Banner
Abstract #3742

Cine-EPI Can Be Used to Detect Adenosine-Induced Myocardial Oxygenation Changes in Canines

Jordin Daniel Green1,2, Matthias Voehringer2, Jacqueline A. Flewitt2, Sven Zuehlsdorff3, John Victor Tyberg2, Matthias G. Friedrich2

1Siemens Healthcare, Calgary, Alberta, Canada; 2University of Calgary, Calgary, Alberta, Canada; 3Siemens Medical Solutions USA, Inc., Chicago, IL, USA

The purpose of this study was to demonstrate that BOLD-sensitive cine-EPI with effective TE=15 ms could detect changes in myocardial oxygenation. We developed a cine-EPI sequence and tested it in dogs with varying degrees of coronary artery stenoses, at rest and during adenosine infusion. We detected statistically significant differences in the response to adenosine in myocardial territories affected by high-grade stenoses compared to territories in the same dog unaffected by the high-grade stenoses.