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Abstract #3766

Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers Within Infarcted Myocardium.

David Sosnovik1, Ruopeng Wang2, Guangping Dai2, Teresa Wang3, Elena Aikawa, Mikhail Novikov4, Anthony Rosenzweig4, Richard Gilbert3, Van Wedeen2

1Martinos Center for Biomedical Imaging, Massachusetts General Hospital,Harvard Medical School, Boston, MA, USA; 2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School; 3Massachusetts Institute of Technology; 4Beth Israel Deaconess Medical Center, Harvard Medical School

We describe in this paper the performance of diffusion spectrum MRI tractography in the myocardium. The technique is used to characterize myofiber architecture in normal as well as infarcted rat hearts. A newly described pattern of orthogonal myofibers is detected in infarcted myocardium, and is of significant relevance to both mechanical and electrical remodelling of the infarcted heart.