Abstract #3766

Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers Within Infarcted Myocardium.

David Sosnovik¹, Ruopeng Wang², Guangping Dai², Teresa Wang³, Elena Aikawa, Mikhail Novikov⁴, Anthony Rosenzweig⁴, Richard Gilbert³, Van Wedeen²

¹Martinos Center for Biomedical Imaging, Massachusetts General Hospital,Harvard Medical School, Boston, MA, USA; ²Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School; ³Massachusetts Institute of Technology; ⁴Beth Israel Deaconess Medical Center, Harvard Medical School

We describe in this paper the performance of diffusion spectrum MRI tractography in the myocardium. The technique is used to characterize myofiber architecture in normal as well as infarcted rat hearts. A newly described pattern of orthogonal myofibers is detected in infarcted myocardium, and is of significant relevance to both mechanical and electrical remodelling of the infarcted heart.