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Abstract #3768

Spatio-Temporal Modeling of First-Pass Perfusion Cardiovascular MRI

Volker J. Schmid1, Guang-Zhong Yang1

1Institute of Biomedical Engineering, Imperial College, London, UK

Myocardial perfusion MRI provides valuable insight into how coronary artery and microvascular diseases affect myocardial tissue. Stenosis in a coronary vessel leads to reduced maximum blood flow (MBF), but collaterals may secure the blood supply of the myocardium but with altered tracer kinetics. To date, quantitative analysis of myocardial perfusion MRI has only been performed on a local level, largely ignoring the contextual information inherent in different myocardial segments. We propose a Hierarchical Bayesian Model (HBM) to quantify the dependencies between local kinetic systems for perfusion quantification. In the proposed framework, all local systems are modelled simultaneously along with their dependencies, thus allowing more robust context-driven estimation of local kinetics. Validation on both simulated and patient data is provided.