A Parametric Model for Quantitative Analysis of Contrast-Enhanced First-Pass MR Myocardial Perfusion That Accounts for Gd-DTPA Interstitial Loading

Li-Yueh Hsu¹, Daniel W. Groves¹, Anthony H. Aletras¹, Peter Kellman¹, Andrew E. Arai¹

Myocardial blood flow of first-pass MR perfusion was estimated using a simple mathematic model in constrained devolution that accounts for loading of the interstitial space with gadolinium contrast. The results of the MR perfusion estimates correlated with a wide range of absolute blood flow measured from microsphere references.