Ziqi Sun1, Tiansheng Wang1, Guanglong He1, Jay L. Zweier1
1Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
Sensitivity-enhanced 2D 31P CSI was applied for early diagnosis of the risk areas in the acute ischemic rat heart. Longitudinal measurements of the PCr-to-ATP ratio in the LAD occluded rat heart showed that the myocardial viability decreased from the peripheral to the central areas of the injured rat heart. This result was further confirmed by the SPIO contrast enhanced MRI. The study indicated that early and accurate diagnosis of myocardium at risk during acute ischemia is possible using sensitivity-enhanced 2D 31P CSI techniques.