Abstract #3775

Early Diagnosis of Myocardial Infarction Areas on Rat Models Using 2D 31P CSI

Ziqi Sun¹, Tiansheng Wang¹, Guanglong He¹, Jay L. Zweier¹

¹Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

Sensitivity-enhanced 2D 31P CSI was applied for early diagnosis of the risk areas in the acute ischemic rat heart. Longitudinal measurements of the PCr-to-ATP ratio in the LAD occluded rat heart showed that the myocardial viability decreased from the peripheral to the central areas of the injured rat heart. This result was further confirmed by the SPIO contrast enhanced MRI. The study indicated that early and accurate diagnosis of myocardium at risk during acute ischemia is possible using sensitivity-enhanced 2D 31P CSI techniques.