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Abstract #3777

Quantification of Myocardial Oxygen Consumption Rate: Initial Experience in Humans

Kyle Stephan McCommis1, Donna Lesniak1, Thomas A. Goldstein1, Pamela K. Woodard1, Robert J. Gropler1, Jie Zheng1

1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

A cardiac MR method is demonstrated to quantify the myocardial oxygen consumption rate at rest and during hyperemia, by using the Ficks principle. MRI data acquisitions were performed in normal volunteers. Each study session consisted of imaging at rest and adenosine-induced vasodilation. Myocardial oxygen consumption rose proportionally with rate-pressure product from the rest condition. Myocardial blood flow correlated well with oxygen consumption at rest, but mismatched during the vasodilation.