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Abstract #3779

Dependence of Myocardial BOLD Contrast on Imaging Parameters at 1.5T: Monte Carlo Simulation and Experiments

Xiangzhi Zhou1, Richard Tang1, Rachel Klein1, Debiao Li1, Rohan Dharmakumar1

1Department of Radiology, Northwestern University, Chicago, IL, USA

The effect of TR and flip angle on SSFP based myocardial BOLD sensitivity was studied using a theoretical model which incorporated diffusion effects through Monte-Carlo simulation. Theoretical results were validated using an animal model with controllable coronary artery stenosis. Both simulations and experimental findings show that SSFP-based myocardial BOLD contrast is directly dependent on TR and flip angle at 1.5T.