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Abstract #3800

Cardiac-Specific GLUT1 Overexpression Preserves Contractile Reserve in Diabetic Mouse Hearts: A Multi-Phase DENSE MRI Study Under Dobutamine-Induced Cardiac Stress

Jia Zhong1,2, Fang Bian1,2, Wei Li1,2, Priyanjana Chaudhuri1, Rong Tian3, Xin Yu1,2

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, USA; 3NMR Laboratory for Physiological Chemistry, Brigham and Womens Hospital, Boston, MA

Diabetes is associated with increased cardiac morbidity and mortality. In our previous study, we found that basal cardiac function in diabetic mice was normalized through improved glucose metabolism via cardiac-specific overexpression of a glucose transporter (GLUT1-TG). In the current study, contractile reserve in GLUT1-TG diabetic mice was examined under dobutamine stimulation using multi-phase DENSE MRI. Our results showed that -adrenergic response was preserved in GLUT1-TG diabetic mice. Therefore, enhanced glucose oxidation and glycolysis has the beneficial effects of preserved contractility and contractile reserve in diabetic mouse hearts.