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Abstract #3822

High-Resolution Ex-Vivo MR Angiography of the Murine Heart Using Langendorff Gd-DTPA Perfusion Technique

Steven F. Tanner1, David Benoist1, Justin F X Ainscough1, Edward White1, Michael E. Ries1, Aleksandra Radjenovic1

1University of Leeds, Leeds, UK

This paper describes a technique for the acquisition of 3D MR angiograms from the ex-vivo murine heart with ~60m isotropic spatial resolution. The technique enables visualisation of the epicardial vessel architecture, and identification of branching vessels with the diameter of ~120m. Alterations in epicardial vessel architecture caused by pathology or genetic variation/modification occurring in vessels of this size (or greater) could therefore become apparent using this approach.