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Abstract #3828

Computational Fluid Dynamics (CFD)-Based Flow Analysis in Aneurysms: A Comparison Study with 4D Phase-Contrast MR in an in Vivo Canine Aneurysm

Jingfeng Jiang1,2, Kevin Johnson1, Oliver Wieben1,2, Oddrun Myklebust3, Kent-Andre Mardal3, Charles Strother2

1Medical Physics, University of Wisconsin, Madison, WI, USA; 2Radiology, University of Wisconsin, Madison, WI, USA; 3Simula Research Lab, Oslo, Norway

This work presents a comprehensive analysis and comparison of the hemodynamics of an experimental canine aneurysm model based on traditional CFD simulations and novel 4D phase-contrast MR measurements. The MR flow measurements were then compared with "image-based" and animal specific CFD simulations using 3D-DSA to obtain aneurysm geometries and ultrasound Doppler/MR measurements for velocity waveforms. Our CFD results as well as 2D Ultrasound Doppler images confirm that 4D PC-MR provides physically-sound velocity measurements and therefore may be potentially used for detailed analysis of the disturbed flow that is usually present in intracranial aneurysms.