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Abstract #3846

Dynamic Contrast-Enhanced MRI Detects Progression of Inflammation in a Rabbit Model of Atherosclerosis

William Sean Kerwin1, Jerry Ricks2, Michael Rosenfeld2

1Radiology, University of Washington, Seattle, WA, USA; 2Pathology, University of Washington, Seattle, WA, USA

This study investiated the association of dynamic contrast-enhanced MRI measurements with macrophage content in experimental lesions of atherosclerosis at different time points in a rabbit model. We found a progressive increase that showed significant correlation with a corresponding increase in macrophage content.