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Abstract #3949

In Vivo Measurement of Cortical Bone Bulk Susceptibility with Ultrashort TE (UTE) Pulse Sequences

Jing-Tzyh Alan Chiang1, Jiang Du1, Atsushi Takahashi2, Robert F. Mattrey1, Graeme Bydder1

1Radiology, University of California San Diego, San Diego, CA, USA; 2Applied Science Laboratory, GE Health Care

Direct MR imaging of cortical bone can be accomplished by ultrashort TE (UTE) pulse sequences that overcome cortical bones extremely short T2. The bulk susceptibility of bone is a parameter of biological interest, and previously it has been measured in vitro in powder form and indirectly in vivo. We present here a simple, direct approach for in vivo measurement of cortical bone bulk susceptibility using phase differences obtained by UTE imaging at two different submillisecond TEs.