Abstract #4003

Intramyocellular Lipids Mobilization in Elderly: Relationships with Physical Activity, Maximal Aerobic Capacity and Insulin Sensitivity

David M. Rouffet^1,2, Rachida Fissoune¹, Christophe Hautier³, Dominique Sappey-Marinier⁴, Martine Laville⁵, Danielle Ibarolla⁴, Monique Sothier⁵, Marie-France Monnet⁶, Michel Ovize⁶, Marc Bonnefoy⁷, Chris Boesch⁸, Emmanuelle Canet-Soulas¹

¹CREATIS LRMN, UMR CNRS #5220, INSERM U630, University of Lyon - Universit Lyon 1, Lyon, Rhone-Alpes, France; ²Centre for Ageing, Rehabilitation Exercise & Sport, Victoria University , Melbourne, Victoria, Australia; ³CRIS EA647, University of Lyon - Universit Lyon 1, France; ⁴CERMEP, University of Lyon - Universit Lyon 1, France; ⁵CRNH, University of Lyon - Universit Lyon 1, France; ⁶Unit de Rducation Cardiaque, University of Lyon - Universit Lyon 1, France; ⁷Service de Mdecine Griatrique, University of Lyon - Universit Lyon 1, France; ⁸Dept.Clinical Research, University Bern, Switzerland

Epidemiological studies show that impairments of the insulin-stimulated glucose metabolism in skeletal muscle initiate type 2 diabetes apparition in elderly subjects. Repeating physical activities throughout entire life may positively affect insulin sensitivity by improving intracellular fat homeostasis in skeletal muscle. 1H nuclear magnetic resonance spectroscopy (1H-MRS) technique offers the possibility to study lipid metabolism by performing repeated and non invasive measurements of intramyocellular lipids (IMCL) content. The objective of this study was to determine if the exercise-induced IMCL mobilization is related to physical activity, maximal aerobic capacity and insulin sensitivity in elderly people.