Guenther Schneider1, Wolfgang Loytved2, Luigi Grazioli3, Richard Semelka4, Gianni Morana5, Miles Andrew Kirchin6, Arno Buecker2, Peter Fries2
1University Hospital of Saarland, Homburg / Saar, Germany; 2University Hospital of Saarland, Germany; 3University of Brescia, Italy; 4University of North Carolina at Chapel Hill, USA; 5General Hospital Ca Foncello, Treviso, Italy; 6Bracco Imaging SpA, Milan, Italy
Gadobenate dimeglumine (MultiHance) and Ferucarbotran (Resovist) are MR contrast agents that can be used for both dynamic and delayed phase imaging of the liver. Whereas MultiHance is a gadolinium agent that undergoes partial uptake by functioning hepatocytes, Resovist is an iron oxide agent that undergoes uptake by Kupffer cells. The present study compared these two agents intra-individually for dynamic and delayed imaging in 43 patients with confirmed hypervascular focal liver lesions in a blinded off-site read. MultiHance was significantly superior to Resovist for lesion detection both when dynamic images were evaluated alone and when comparison was made of all available image sets.