Fatty Acid Composition of Subcutaneous Fat and Bone Marrow in Human Calf Is Affected by Diet and Exercise: an 1H-MRSI Study at 4T

Min-Hui Cui^1,2, Jong Hee Hwang^1,2, Vlad Tomuta², CJ Segal-Isaacson², Daniel T. Stein²

High-quality in vivo proton NMR spectra from human calf adipose tissue and bone marrow can be obtained by using ¹H-MRSI at 4T. This technique can effectively detect differences in fatty acid (FA) composition among subjects undergoing diet or exercise. Athletic subjects have a higher fraction of monounsaturated and lowest saturated content of FA compared to sedentary subjects. On the other hand, the diet and weight loss affect FA composition. The fraction of diunsaturated FA improved and that of saturated FA decreased after a low fat diet, as well as after moderate weight loss.