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Abstract #4031

Evaluation of Low and High B-Values for the Differentiation Between Pancreatic Carcinoma and Chronic Pancreatitis Using Diffusion-Weighted Imaging

Miriam Klauss1, Andreas Lemke2, Katharina Grnberg2, Moritz N. Wente3, Hans-Ulrich Kauczor1, Stefan Delorme2, Lars Grenacher1, Bram Stieltjes2

1Interventionel and diagnostic Radiology, University Hospital, Heidelberg, Baden-Wrttemberg, Germany; 2DKFZ, Heidelberg; 3Universitiy Hospital, Heidelberg

We evaluated the value of different b-values to differentiate between pancreatic carcinoma and chronic pancreatitis using DWI. Nineteen patients received DWI (b= 25-800s/mm2). Histopathologically, 13 had pancreatic carcinoma and 6 chronic pancreatitis. We measured the ADC within the lesions for all b-values. The difference in ADC was tested using a Mann-Whitney-U-Test. The results showed significant differences between the ADCs of pancreatic carcinoma and chronic pancreatitis at low b-values (b=75, 100, 150 and 200). At higher b-values (>300), the differences did not reach significance. In conclusion, for the differentiation between pancreatic carcinoma and chronic pancreatitis, low b-values outperform high b-values.