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Abstract #4055

Hepatocellular Carcinoma (HCC) with Portal Venous Tumor Thrombosis (PVTT) Response to Yttrium-90 Radioembolizaion Evaluated by Functional MRI

Yi Wang1, Robert J. Mccarthy2, Paul Nikolaidis3, Vahid Yaghmai3, Laura Merrick3, Andrew Larson3, Reed Omary3, Robert Lewandowski3, Riad Salem3, Frank H. Miller3

1Radiology , Northwestern University , Chicago , IL, USA; 2Anesthesia, Northwestern University, USA; 3Radiology, Northwestern University, Chicago, IL, USA

We assessed DWI compared with contrast-enhanced MR in the evaluation of early HCC and PVTT response to 90Y radioembolization. ADC and percentage enhancement of tumor and thrombosis were calculated in 25 patients. AFP, tumor size, change in percentage necrosis and follow-up were used as combined reference standards. ADC of tumor increased from baseline 1.42 (10-3mm2/s) to 1.65 after treatment (p<0.05) and ADC of PVTT also increased from 1.29 to 1.54 (p<0.05). Based on reference standards, ADC change was significantly better to predict tumor and thrombosis response to treatment compared to percentage enhancement which was not helpful for early response. <