Kiminori Fujimoto1,2, Tatsuyuki Tonan1, Shuji Nagata1, Sanae Azuma1, Osamu Nakashima3, Masayoshi Kage3, Takumi Kawaguchi4, Naofumi Hayabuchi1, Koji Okuda5, Takeshi Johkoh6
1Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; 2Center for Diagnostic Imaging, Kurume University Hospital, Kurume, Fukuoka, Japan; 3Department of Pathology, Kurume University School of Medicine, Kurume, Japan; 4Department of Medicine, Kurume University School of Medicine, Kurume, Japan; 5Department of Surgery, Kurume University School of Medicine, Kurume, Japan; 6Department of Radiology, Kinki Central Hospital, Itami, Japan
The aim of study was to evaluate mean of region-of-interest and volume histogram analysis of signal intensities obtained by diffusion-weighted (DW)-MRI and superparamagnetic iron oxide (SPIO)-MRI for predicting the histopathologic liver fibrosis and inflammation scores and clinical severity. The study included 34 patients with chronic hepatitis C and 9 patients without hepatic dysfunction were retrospectively evaluated. The quantitative analysis of ADC values (DW-MRI) and reduction percentage of liver-to-muscle signal intensity ratio (SPIO-MRI) is helpful in predicting the histopathologic liver fibrosis as well as clinical severity in patients with chronic hepatitis.