Reproducibility of ADC Measurements of Abdominal Organs at 1.5T and 3T

Andrew Rosenkrantz¹, Marcel Oei¹, Hersh Chandarana¹, Bachir Taouli¹

Reproducibility of ADC (apparent diffusion coefficient) measurements is extremely important for the design of drug trials and prospective protocols involving DWI in the abdomen. Three volunteers underwent baseline and follow-up abdominal DWI at both 1.5T and 3T, and coefficients of variation (CV) of ADC of abdominal organs were calculated for both field strengths. ADC of kidney, pancreas, and spleen showed excellent reproducibility at 1.5T and 3T, but reproducibility of liver ADC was moderate at both field strengths. There was no significant difference in CV of ADC between field strengths. Our preliminary data supports use of serial ADC measurements in the abdomen, with some caution warranted when applied in the liver.