Quintuple Arterial Phase Gd-EOB-DTPA Enhanced Dynamic MR Imaging with Interleaved Stochastic Trajectories for Hepatocellular Carcinoma

Satoru Kitano¹, Nagaaki Marugami¹, Junko Takahama¹, Aya Hashimoto¹, toshiaki Taoka¹, shinji Hirohashi², kimihiko Kichikawa¹

Gd-EOB-DTPA is a new hepatobiliary MRI contrast agent, detection and characterization of liver tumors. This compound is taken up by the hepatocytes and is equally excreted renal and biliary in humans. Dynamic and accumulation phase imaging can also be performed after bolus injection of Gd-EOB-DTPA. Time-resolved MR angiography (MRA) offers the combined advantage of large anatomic coverage and hemodynamic flow information. We applied parallel imaging and time-resolved imaging with stochastic trajectories (TWIST) to perform Gd-EOB-DTPA enhanced dynamic MRI for hepatocellular carcinoma. We obtained quintuple arterial phase dynamic MR imaging and time resolved MR angiography simultaneously. The purpose of this study was to describe and validate the use of time resolved Gd-EOB-DTPA enhanced MRI for the noninvasive assessment of hemodynamics and hepatocytes functional information of hypervascular hepatocellular carcinoma.