Abstract #4075

Kinetic Analysis of Gd-EOB Uptake by Hepatocytes with Gd-EOB-Enhanced Dynamic MR Imaging

Hiromitsu Onishi¹, Tonsok Kim¹, Masatoshi Hori¹, Takamichi Murakami², Takahiro Tsuboyama¹, Mitsuaki Tatsumi¹, Atsushi Nakamoto¹, Yasuhiro Nakaya¹, Kaname Tomoda¹, Hironobu Nakamura¹

¹Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; ²Department of Radiology, Kinki University School of Medicine, Osakasayama, Osaka, Japan

The purpose of the present study was to analyze the kinetics in the uptake of Gd-EOB by the hepatocytes by using a Michaelis-Menten model. Uptake rate and concentration of Gd-EOB was estimated from Gd-EOB-enhanced dynamic MR imaging data. To evaluate whether the relationship between the uptake rate and the Gd-EOB concentration obey Michaelis-Menten kinetics, an Eadie-Hofstee Plot was analyzed. A Hanes-Woolf Plot was also generated to obtain an apparent Michaelis constant.