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Abstract #4097

Getting More Out of 31P MRS of the Human Liver Moving from 1.5T to 3T

Ronald Ouwerkerk1, Alena Horska1,2, Michael Schr3, Susanne Bonekamp1, Mariana Lazo4, Jeanne M. Clark4,5

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Neuroradiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Philips Healthcare, Cleveland, OH, USA; 4Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 5Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

An upgrade from 1.5T to 3T is expected to improve 31P liver MRS, but causes continuity problems in a longitudinal study. ISIS-localized and 1H-decoupled 31P MR spectra, recorded with nearly identical acquisition parameters and localized volumes at 1.5T and 3T were analyzed for changes in quality and quantitation of metabolites. Relative signals of β-ATP and PME were the same for both fields, but different for other metabolites. Higher field yielded a marked improvement in potential to detect low level di-phosphate metabolites, individual phospho-monoesther (PME) and -phospho-diester peaks and enabled accurate measurement of intracellular pH from the inorganic phosphate shifts.


Exhibit Hall 2-3 Thursday 13:30-15:30 Computer 63