Abstract #4123

Clinicopathological Correlation of Residual Breast Cancer Diagnosed by MRI in Patients Receiving Neoadjuvant Chemotherapy with and Without Bevacizumab (Avastin)

Shadfar Bahri¹, Jeon-Hor Chen^1,2, Ke Nie¹, Rita S. Mehta³, Philip M. Carpenter⁴, Soon-Young Kwon⁴, Hon J. Yu¹, Orhan Nalcioglu¹, Min- Ying Su¹

¹Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; ²Department of Radiology, China Medical University Hospital, Taichung, Taiwan; ³Department of Medicine, University of California, Irvine, USA; ⁴Department of Pathology, University of California, Irvine, USA

The pathological response in breast cancer patients receiving anti-angiogenic therapy using Avastin, and the impact of Avastin on diagnostic performance of MRI after therapy was investigated. The pCR rates and residual disease patterns were comparable between patients receiving Avastin vs. those not. The size measured on MRI was highly accurate for mass lesions that shrank down to nodules. For residual disease as scattered cells within a large fibrotic region, MRI could not predict them accurately. The fact that the accuracy of MRI was comparable between 2 groups suggests that treatment with Avastin did not compromise the diagnostic accuracy of MRI.