Measurement Accuracy of a Gadolinium Enhanced Magnetic Resonance Imaging Technique for the Measurement of Kidney Glomerular Filtration

Khalil Nabeel Salman¹, Saravanan Kokila Krishnamoorthy¹, Puneet Sharma¹, Bobby Kalb¹, Dana Tudorascu², Diego R. Martin¹

Glomerular filtration rate (GFR) can be determined by MRI perfusion-filtration techniques using rapid volumetric perfusion imaging after administration of a filtered gadolinium-chelate. Several methods have been employed but there remains the need to increase the body of evidence validating each of the proposed models. We have been developing a methodology based on a 3-compartment kinetic model that accounts for the renal vascular, interstitial, and filtered compartments. In this study we compare the concurrent measurement of GFR by our MRI technique and by conventional creatinine-clearance technique in a series of patients. We show that the two methods are highly correlated.