Moganty Raja Rajeswari1, Uma Sharma1, N. R. Jagannathan2, Ashok Sharma1
1Biochemistry, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India
We used MRI to study the pharmacodynamics of bleomycin and doxorubicin on squamous cell carcinoma (SCC) of skin in mice, in order to get insights of prognosis and treatment strategies. Using MRI parameters, tumor volume, proton relaxation times, T1 and T2, we demonstrate the higher potency of doxorubicin as compared to bleomycin in treating skin tumors of SCC origin.. Results were further corroborated with biochemical parameters like proliferation and apoptotic index. Therefore study highlights the potential of MRI in detecting the efficacy or the resistance of anticancer drug on skin tumors.
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