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Abstract #4201

Multiparametric MRI/MRS and Gene Expression Profiling for Monitoring Docetaxel Effects in MCF7 Xenografts

Else Marie Huuse1, Line Rrstad Jensen1, Pl Erik Goa1,2, Steinar Lundgren1,3, Endre Anderssen4, Tone Frost Bathen1, Ingrid Susanne Gribbestad1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 2Department of Radiology, St. Olavs University Hospital, Trondheim, Norway; 3Department of Oncology, St. Olavs University Hospital , Trondheim, Norway; 4Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway

Sensitive methods are needed to assess early tumor response and obtain individualized treatment based on biological characterization of tumors. DCE-MRI, ADC-mapping and in vivo MRS combined with gene expression of tissue samples and multivariate data analysis, have been used to study changes during tumor progression and early effects of docetaxel in MCF7 xenografts. Our findings indicate that docetaxel treatment cause a significant increase in water diffusion, a significant change in v_e and distinct differences in the in vivo metabolite and gene expression profiles of controls and docetaxel treated tumors.