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Abstract #4222

Hepatic Perfusion Quantification Using a Dual-Input Kinetic Model with a Novel Portal Venous Estimation Method: Evaluation Against Other Model- And Slope-Based Perfusion Quantification Approaches

Keiko Miyazaki1, Matthew R. Orton1, Dow-Mu Koh1, V Lewington2, David Atkinson3, David J. Hawkes3, Martin O. Leach1, David J. Collins1

1Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of Cancer Research, Sutton, Surrey, UK; 2Department of Nuclear Medicine and PET, The Royal Marsden NHS Foundation Trust, Sutton, UK; 3Centre for Medical Image Computing, University College London, London, UK

Hepatic perfusion quantification can be performed via kinetic modelling of dynamic contrast enhanced (DCE-) MR data using a dual-input single compartment model. A methodology which estimates portal venous contributions directly from liver tissue DCE-MR data, has been developed and submitted to this conference. In this study, we have quantified hepatic perfusion in clinical patient data using the novel model-based approach. The perfusion metrics obtained compared favourably with those quantified using a dual-input single compartment model with population-averaged arterial and portal input functions and a dual slope, modified Blomley method.