Kyung K. Peck1, Gregg Slater2, Xiuyuan Wang3, SeungEun Kim4, Josh Yamada5, Mark Bilsky6, Eric Lis2, Sasan Karimi2
1Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA; 2Neuroradiology, Memorial Sloan-Kettering Cancer Center, New York, USA; 3The City Unversity of New York, New York, USA; 4Stony Brook University, New York, USA; 5Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA; 6Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, USA
Application of DCE MRI to the study of bone marrow between ages, sex subgroups, and among spinal levels has already shown variations in bone marrow time intensity curves. Since these differences influence the appearance of the marrow and its dynamic profile we sought to investigate the utility of DCE MRI. We investigated the bone marrow of the spine using a contrast enhanced dynamic perfusion MRI, and the parameter measured was the bolus wash-in slopes. Significant Statistical differences in the enhancement percentage signal change were found between hypervascular and hypovascular tumor groups. A trend showing statistical differences was found using enhancement slope measurement. The signal in normal marrow as compared to tumors showed no significant enhancement patterns.
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