Abstract #4230

Improved Characterization of Breast Lesions with Relative ADC Accounting for Tissue Composition Variation

Jie Huang¹, Lori Hoisington¹, Tobias Hahn^1,2, Anna Babayan³, Kevin Berger¹

¹Department of Radiology, Michigan State University, East Lansing, MI, USA; ²Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA; ³College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA

DWI has been used recently to investigate the potential application of ADC in the characterization of breast lesions. Studies found that the ADC of malignant tumors was significantly smaller than that of benign lesions, reflecting increased cellularity of the malignant tumors. However, breast tissue composition varies substantially from person to person and could mask the effect of cellularity changes on ADC. In this study we investigated the correlation between the ADC of breast lesions and the ADC of the immediate surrounding tissues and then examined the effect of tissue composition variation on the characterization of the breast lesions.