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Abstract #4247

Evaluating Prognostic Biomarkers of Prostate Cancer Behaviour: Use of Magnetization Transfer and Diffusion Weighted Contrast

Sophie Riches1, Vonnie A. Morgan1, David J. Collins1, Sharon Giles1, Nandita M. deSouza1

1CRUK Clinical Magnetic Resonance Group, Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, Surrey, UK

Investigating the correlation of apparent diffusion coefficients (ADCs and magnetization transfer ratios (MTRs) may offer greater understanding of underlying tissue structure in prostatic tumors. This study determined the T2 values, ADCs and MTRs and the correlation between them in normal regions of the prostate and prostate tumors. A positive correlation between T2 and ADC, and a negative correlation between MTR and both T2 and ADC suggests that MTR imaging in the prostate warrants investigation with ADC as a prognostic biomarker.