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Abstract #4252

Identification and Analysis of Metabolic Biomarkers for Predicting Prostate Cancer Grades Using 1H HR-MAS Spectroscopy of Biopsy Tissues

Vickie Zhang1,2, Maria Grinde3,4, Laura Tabatabai5, Jeff Simko5, Mark Albers1, Daniel Vigneron1, John Kurhanewicz1

1Radiology, University of California, San Francisco, San Francisco, CA, USA; 2Joint Bioengineering Program, University of California, Berkeley/San Francisco, San Francisco, CA, USA; 3Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 4St.Olav University Hospital, Trondheim, CA, Norway; 5Pathology, University of California, San Francisco, San Francisco, CA, USA

This study used quantitative 1-D 1H HR-MAS spectroscopy of snap frozen prostate biopsies to investigate the metabolic profiles of high (Gleason score ≤ 3+3) versus low pathologic grade (Gleason score ≥ 3+4) prostate cancer. Significantly higher concentrations of GPC, free choline, PE, alanine and glutamine were observed in high-grade versus low-grade prostate cancer. The concentration of lactate was also found to be higher in high-grade prostate cancer but this was not significant. By combining these metabolic changes, it may be possible to metabolically discriminate indolent from aggressive prostate cancer.