Improved Spectral Resolution in 2D Localized Correlated Spectroscopy Using Enhanced Covariance NMR

Neil Wilson¹, Enrique Frias-Martinez¹, Michael Albert Thomas¹

Resolution along the indirect dimension (t1) is limited by the number of increments used for achieving the 2nd spectral axis in localized 2D MRS, thus leading to lower resolution along t1 compared to the detected dimension (t2). Covariance NMR has been extended to processing the 2D data to achieve equal resolution along both spectral dimensions (F2, F1) even though 2-3% of t2 points were only used for t1. While using limited t1 points, occurrence of false cross peaks was minimized using an enhanced covariance NMR method and pilot evaluations using phantom solutions and in vivo brain show promising results.