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Abstract #4275

In Vivo Animal NMR Studies Using Implantable Micro-Coil

Aziz Kadjo1, Nicoleta Baxan2, Raymond Cespuglio3, Andr Briguet1, Colette Rousset3, Minh Dung Hoang1, Danielle Graveron-Demilly1, Latifa Fakri-Bouchet1

1CREATIS-LRMN, UMR CNRS 5220, INSERM U 630, INSA de Lyon, Universit Lyon 1, Villeurbanne, France; 2Medical Physics Department of Diagnostic Radiology, University Hospital Freiburg, Freiburg, Germany; 3Laboratoire Radicaux libres/substrats nergie et physiopathologie crbrale. EA 4170, Universit Lyon1,, France

The feasibility to use a new generation of micro-coils was proposed in a recent study. It demonstrated to have potential opportunities in terms of increased signal-to-noise ratio (SNR), spatial resolution, and limits of detection (LOD), compared to the surface-coil. The originality of the present work is to show how to realize brain implantable NMR detectors, tolerated by rats for several weeks. To the best of our knowledge, no in vivo study has been already done with such sensors. Reinforced by acquisition and signal processing, it aims at pushing the limits of in vivo detection and an ultra localisation technique should result from this approach.