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Abstract #4278

Quantification of Short-TE Metabolite Signals in Human Brain Using QUEST and a Simulated Basis Set

Hyeon-Man Baek1, Sergey Cheshkov1,2, Audrey J. Chang1, Richard W. Briggs1,2

1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; 2Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA

In this study, in vivo quantification of short-TE metabolite signals measured in the basal ganglia was performed with QUEST (using jMRUI software) using a simulated metabolite basis set. The measured metabolite concentrations in this work were consistent with the reported values in the literature (Govindaraju et al.). Our results suggested that six metabolites (NAA, Ins, Cr, Cho, Glu, and Glx) can be reliably quantified in human basal ganglia (voxel size, 2x3x2 cm3) at short TE at 3T. However, it was not possible to quantify other metabolites such as GABA CRLB = 33%) and Gln (CRLB = 58%). <